| Bioactivity | MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM[1]. | ||||||||||||
| Target | IC50: 5 nM (MALT1)Kd: 13 nM (MALT1(329-728)-W580S), 42 nM (MALT1(329-728)) | ||||||||||||
| Invitro | MLT-748 reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM)[1].MLT-748 (0-2 μM) stabilizes cellular MALT1-W580S, with an EC50 of 69 nM[1].MLT-748 (2 µM, 24 hours) increases the phosphorylation of p65 and IκBα in MALT1mut/mut patient immortalized B cells[1]. Western Blot Analysis Cell Line: | ||||||||||||
| Name | MLT-748 | ||||||||||||
| CAS | 1832578-30-9 | ||||||||||||
| Formula | C19H19Cl2N9O3 | ||||||||||||
| Molar Mass | 492.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313. |
MLT-748
CAS: 1832578-30-9 F: C19H19Cl2N9O3 W: 492.32
MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an I
Data collection：peptidedb@qq.com
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