TAM-16_product_DataBase

Bioactivity	TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC50 value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel[1][2].
Invitro	TAM-16 (compound 1) 抑制 M. tuberculosis 菌株 H37Rv，IC50 值为 0.08 μM[1]。TAM-16 (0-10 μM) 通过靶向 Pks13 抑制 Mycobacterium tuberculosis[1]。
In Vivo	TAM-16 (compound 1; 200 mg/kg; p.o.; 每日一次, 持续 14 天) 可防止小鼠 TB 感染模型出现特征性肺部病变[2]。 Animal Model:
Name	TAM-16
CAS	2030241-59-7
Formula	C22H24N2O4
Molar Mass	380.44
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Scullion P, et, al. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. J Med Chem. 2022 Jan 13;65(1):409-423. [2]. Aggarwal A, et, al. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell. 2017 Jul 13;170(2):249-259.e25.

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