| Bioactivity | SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM[1][2][3][4]. |
| Invitro | SCH-202676 (compound 6a) (0.01-10 µM；0、5、10 和 20 min) 具有抗病毒活性并以时间依赖的方式抑制 3CLpro，在 0、5、10 和 20 分钟的 IC50 值分别为 0.409、0.302、0.206 和 0.191 µM[1]。SCH-202676 (10 μM；90 min) 加强了大鼠前脑膜中 [35S]GTPγS 的标记[2]。SCH-202676 抑制激动剂 [3H]UK-14,304 (HY-B0659) 和拮抗剂 [3H] 育亨宾 (Yohimbine，HY-12715) 与 α2a 肾上腺素能受体的结合[3]。SCH-202676 (10 μM) 选择性地加速了激动剂在腺苷 A3 受体上的解离，减慢了拮抗剂在腺苷 Ai 受体上的解离，加速了拮抗剂在腺苷 AzA 受体上的解离[4]。 |
| Name | SCH-202676 |
| CAS | 70375-43-8 |
| Formula | C15H13N3S |
| Molar Mass | 267.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129. [2]. Lewandowicz AM, et al. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br J Pharmacol. 2006 Feb;147(4):422-9. [3]. Fawzi A B, et al. SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors[J]. Molecular Pharmacology, 2001, 59(1): 30-37. [4]. Gao ZG, et al. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 2004 May 7;74(25):3173-80. |
SCH-202676
CAS: 70375-43-8 F: C15H13N3S W: 267.35
SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has
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