| Bioactivity | TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC50=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC50 values of 0.96 nM and 1.6 nM for human and rat, respectively[1]. TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer[1][2][4]. |
| Invitro | TAK-683 exhibits an IC50 value (95% CI) from receptor binding assays is 150-180 pM and EC50 value (95% CI) from Ca+ mobilization assays is 180 (159–203) pM in rat KISS1R-expressing Chinese hamster ovary (CHO) cells[4]. |
| Name | TAK-683 |
| CAS | 872719-49-8 |
| Sequence | N-Acetyl-Tyr-Trp-Asn-Thr-Phe-{aza}-Leu-{Met-Arg}-Trp-NH2 |
| Shortening | N-Acetyl-YWNTF{aza}L{Met-R}W-NH2 |
| Formula | C64H83N17O13 |
| Molar Mass | 1298.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
TAK-683
CAS: 872719-49-8 F: C64H83N17O13 W: 1298.45
TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC50=170 pM) with improved metabolic stability. TAK-683 is a n
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