| Bioactivity | T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase[1]. | ||||||||||||
| Invitro | T2AA(15 μM, 72 h) 抑制链间 DNA 交联（ICL）修复，它可以阻止作为 ICL 修复中间体形成的 DNA 双链断裂（DSB）的分解，具有抑制 DSB 修复的能力[1]。 | ||||||||||||
| Name | T2AA | ||||||||||||
| CAS | 1380782-27-3 | ||||||||||||
| Formula | C15H15I2NO3 | ||||||||||||
| Molar Mass | 511.09 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Akira Inoue, et al. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem. 2014 Mar 7;289(10):7109-7120. |