| Bioactivity | Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity[1][2][3]. | |||||||||
| Invitro | Swainsonine (0-40 µM; 12 h) shows antiproliferative activity in U251 and LN444 cells[2].Swainsonine (30 µM; 12 h) induces apoptosis and cell cycle arrest at G2/M phase, and decreases the expression of CyclinD1 and CDK4 protein levels, increases the expression of p16 protein level[2].Swainsonine (30 µM; 12 h) reduces glioma cell migration and invasion[2]. Cell Viability Assay[2] Cell Line: | |||||||||
| Name | Swainsonine | |||||||||
| CAS | 72741-87-8 | |||||||||
| Formula | C8H15NO3 | |||||||||
| Molar Mass | 173.21 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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