| Bioactivity | Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2]. | ||||||||||||
| Invitro | The IC50 value of Aristeromycin against AHCY is 38.5 nM at 50 μM S-adenosylhomocysteine (SAH) (approximately equal to the Km: 48 μM), but 271 nM at 1000 µM SAH (20× Km). With 60 min of preincubation, the mean IC50 value of Aristeromycin at 50 μM SAH is 12.7 nM[1].Aristeromycin has IC50 values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth[1].At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a[1]. | ||||||||||||
| Name | Aristeromycin | ||||||||||||
| CAS | 19186-33-5 | ||||||||||||
| Formula | C11H15N5O3 | ||||||||||||
| Molar Mass | 265.27 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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