| Bioactivity | Sulmazole is a cardiotonic agent. Sulmazole has competitive inhibitory for A1 adenosine receptor. Sulmazole can improve cardiac index and reduce pulmonary capillary wedge pressure[1]. |
| Invitro | Sulmazole has competitive inhibitory for A1 adenosine receptors[1].Sulmazole attenuates the capacity of GTP to inhibit adenylate cyclase activity and covalent modification of Gi by pertussis toxin treatment abolishes the capacity of sulmazole to mediate stimulation[1].Sulmazole has stimulatory effect on adenylate cyclase activity in pertussis toxin-treated membranes[1].Sulmazole mediates increases in cAMP accumulation by mechanisms other than phosphodiesterase inhibition, including A1 adenosine receptor antagonism and inhibition of Gi function[1]. |
| Name | Sulmazole |
| CAS | 73384-60-8 |
| Formula | C14H13N3O2S |
| Molar Mass | 287.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. W J Parsons, et al. The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi. Mol Pharmacol. 1988 Apr;33(4):441-8. |