| Bioactivity | CCG-271423 is a potent and selective GRK5 inhibitor with IC50 values of 0.0021 μM and 44 μM for GRK5 and GRK2, respectively. CCG-271423 inhibits cardiomyocyte contractility and decreases in Ca2+ transience[1]. |
| Target | IC50: 0.0021 μM (GRK5) and 44 μM (GRK5) |
| Invitro | CCG-271423 (1 μM) does not alter cardiomyocyte contractility and decreases in Ca2+ transience[1]. |
| Name | CCG-271423 |
| CAS | 2750413-88-6 |
| Formula | C28H26N4O3 |
| Molar Mass | 466.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rowlands R, et, al. Expanding the Arsenal: Development of G-Protein Receptor Kinase 5 Inhibitors Utilizing a Covalent Strategy. |
CCG-271423
CAS: 2750413-88-6 F: C28H26N4O3 W: 466.53
CCG-271423 is a potent and selective GRK5 inhibitor with IC50 values of 0.0021 μM and 44 μM for GRK5 and GRK2, respect
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