Steroid sulfatase-IN-4_product_DataBase

Bioactivity	Steroid sulfatase-IN-4 (Compound 16) is an irreversible steroid sulfatase (STS) inhibitor with an IC50 of 25 nM against human STS. Steroid sulfatase-IN-4 can be used for the research of endometriosis[1].
Target	IC50: 25 nM (hSTS in cellular assays)
Invitro	Steroid sulfatase-IN-4 (Compound 16) shows good metabolic stability in human hepatic S9 fraction and low intrinsic clearance Clint (<30 μL/min/mg protein)[1]. Steroid sulfatase-IN-4 (20 μM; 24 h) shows cytotoxicity for HEK-293 cells (53.6% inhibition)[1].Steroid sulfatase-IN-4 (1 μM) shows 25% inhibition against human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) in a cell-free assay[1].
Name	Steroid sulfatase-IN-4
Formula	C19H17ClN2O5S
Molar Mass	420.87
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mohamed A, et al. Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. J Med Chem. 2022 Aug 22.

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