| Bioactivity | 5'-Methoxynobiletin is a potent and orally active antinociceptive and anti-inflammatory agent. 5'-Methoxynobiletin is a polymethoxyflavone, that can be isolated from A. conyzoides[1][2]. |
| In Vivo | 5'-Methoxynobiletin (5mg /kg, 腹腔注射) 可显著降低白细胞计数、中性粒细胞流入和渗出液中的蛋白质浓度，并降低几种促炎介质的水平[2]。5'-Methoxynobiletin (100 mg/kg，口服，一次) 显示出抗伤害和抗炎活性[2]。5'-Methoxynobiletin (10 mg/kg，静脉注射；50 mg/kg，口服；一次) 在大鼠体内的口服生物利用度较低，约为 8-11%[2]。 Animal Model: |
| Name | 5'-Methoxynobiletin |
| CAS | 6965-36-2 |
| Formula | C22H24O9 |
| Molar Mass | 432.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Faqueti LG, et al. Antinociceptive and anti-inflammatory activities of standardized extract of polymethoxyflavones from Ageratum conyzoides. J Ethnopharmacol. 2016 Dec 24;194:369-377. [2]. Faqueti LG, et al. Preclinical Pharmacokinetic and Pharmacodynamic Investigation of 5'-Methoxynobiletin from Ageratum conyzoides: In vivo and In silico Approaches. Pharm Res. 2022 Sep;39(9):2135-2145. |
5'-Methoxynobiletin
CAS: 6965-36-2 F: C22H24O9 W: 432.42
5'-Methoxynobiletin is a potent and orally active antinociceptive and anti-inflammatory agent. 5'-Methoxynobiletin is a
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