| Bioactivity | Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis. Sparfosic acid trisodium synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines[1][2][3]. |
| Invitro | Sparfosic acid (N-(Phosphonacetyl)-L-aspartate, PALA) treatment causes apoptosis in the resistant Br1 cells[1].Sparfosic acid (PALA, 300 µM) shows progressive accumulation of cells in S phase and activation of an apoptotic pathway leading to cell death[1]. Cell Cycle Analysis[1] Cell Line: |
| Name | Sparfosic acid trisodium |
| CAS | 70962-66-2 |
| Formula | C6H7NNa3O8P |
| Molar Mass | 321.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -80°C, protect from light, stored under nitrogen |
Sparfosic acid trisodium
CAS: 70962-66-2 F: C6H7NNa3O8P W: 321.06
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase.As
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