Licochalcone B_product_DataBase

Bioactivity	Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction[1][2][3][4].
Invitro	Licochalcone B (IC50: 2.16 μM) 抑制 Aβ42 聚集并分解 Aβ42 预先形成的原纤维[1]。Licochalcone B (0-12 μM，48 h) 在 SH-SY5Y 细胞中减少 ROS 的产生并保护细胞免受 H2O2 诱导的细胞死亡[ 1].Licochalcone B (10 μM，1 h) 抑制 RAW264.7 细胞中 LPS 诱导的 NF-κB 激活[2]。Licochalcone B (10 μM，1 h）抑制 LPS 诱导的 NF-κB p65 276 位丝氨酸磷酸化，并抑制 TNFα 和 MCP-1 的表达[2]。Licochalcone B (0-20 μM，24 或 48 h) 抑制人 NSCLC 细胞生长[3]。 Western Blot Analysis[2] Cell Line:
Name	Licochalcone B
CAS	58749-23-8
Formula	C16H14O5
Molar Mass	286.28
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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