Solasodine hydrochloride

CAS: 6106-33-8 F: C27H44ClNO2 W: 450.10

Solasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodi

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Bioactivity	Solasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine hydrochloride induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine hydrochloride has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities[1][2][3].
Invitro	Solasodine（90 μM；2 天）hydrochloride 治疗显示 P19 细胞中出现明显发芽。Solasodine hydrochloride 诱导所研究的不同神经元标志物的强烈表达，包括 βIII-微管蛋白、突触素、MAP2、ChAT 和神经母细胞标志物双皮质素。Solasodine hydrochloride 诱导 P19 细胞分化，主要是向神经通路分化[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Solasodine hydrochloride 相关抗体:
In Vivo	Solasodine（25-100 mg/kg；腹膜内注射；一次）hydrochloride 治疗显著延迟 PCT 诱发的抽搐中后肢强直伸肌 (HLTE) 期的潜伏期。并以剂量依赖性方式显著增强硫喷妥钠诱发的睡眠。 Solasodine hydrochloride 具有抗惊厥和抑制中枢神经系统的作用[2]。Solasodine（375 μM；侧脑室注射；持续 2 周）hydrochloride 治疗可显著增加室管膜层、脑室下区和皮质细胞对溴脱氧尿苷的摄取，这些细胞与双皮质素免疫染色共定位。Solasodine hydrochloride 对大鼠的治疗可显著增加室管膜细胞中胆固醇和药物结合转运蛋白的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	6106-33-8
Formula	C27H44ClNO2
Molar Mass	450.10
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lecanu L, et al. The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo. Neuroscience. 2011 Jun 2;183:251-64. [2]. Akhtar S, et al. Evaluation and Elucidation Studies of Natural Aglycones for Anticancer Potential using Apoptosis-Related Markers: An In silico Study. Interdiscip Sci. 2018 Jun;10(2):297-310.

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