| Bioactivity | A 65281 is a potent DNA gyrase inhibitor with an IC50 value of 0.1 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II. A 65281 induces P4 DNA unknotting with an IC50 value of 8 µg/mL[1]. |
| CAS | 111279-49-3 |
| Formula | C17H16F2N4O2S |
| Molar Mass | 378.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kohlbrenner WE, et al. Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282. Antimicrob Agents Chemother. 1992 Jan;36(1):81-6. |
A 65281
CAS: 111279-49-3 F: C17H16F2N4O2S W: 378.40
A 65281 is a potent DNA gyrase inhibitor with an IC50 value of 0.1 µg/mL. A 65281 induces DNA breakage mediated by calf
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.