| Bioactivity | Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent. | ||||||
| In Vivo | Protocal for preparing 0.5% CMC-Na SolutionMeasure 0.5g of dry CMC-Na and dissolved in 100 ml ddH2O/0.9% Saline (0.9 g NaCl in 100 ml ddH2O) to make a clear solution. Under the condition of stirring and heating (50-65°C), adding CMC-Na slowly to ddH2O/0.9% Saline helps to accelerate dissolution. Note1.You must ensure that your CMC-Na solution does not exist solid-liquid separation phenomenon. The solution is in a uniform and transparent state has no particles in it.2.Completely dissolution of CMC-Na may requires 4 hours or more longer. In a pharmacological test, CMC-Na (oral;5% in water; 1 year) is well tolerated in rats[2].In an acute oral toxicity study in female mice, LD50 of CMC-Na for female mice is 14 g/kg body weight of mice, equivalent to 9.8 g/kg body weight of rat, categorized as practically non-toxic according to Loomis criteria (LD50 5-15g/kg body weight of rat)[3]. | ||||||
| Name | Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s) | ||||||
| CAS | 9004-32-4 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
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| Reference | [1]. Du XH, et al. Dexamethasone and sodium carboxymethyl cellulose prevent postoperative intraperitoneal adhesions in rats. Braz J Med Biol Res. 2015 Apr;48(4):344-8. [2]. Common Vehicles for Nonclinical Evaluation of Therapeutic Agents. [3]. Ida Musfiroh, et al. Toxicity Evaluation of Na-CMC synthesized from Cellulose of Water Hyacinth (Eichhornia crassipes (Mart.) Solms).ISSN: 0975-8585 |
Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s)
CAS: 9004-32-4 F: W:
Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently
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