Tyloxapol

CAS: 25301-02-4 F: (C15H21O(C2H4O)m)n W: 261.38 (monomer)

Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface activ

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Bioactivity	Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol (Triton WR1339) is used to induce hyperlipidemia in animals[1][2].
Invitro	Tyloxapol (100 μg/mL) triggers the detachment of HEK293 cells[2].Tyloxapol induces nuclear fragmentation and the appearance of apoptotic nuclei[2].Tyloxapol increases the risk of pulmonary haemorrhage, causes cytotoxicity in epithelial and red blood cells, and induces lysis of human Jurkat T-lymphoblasts[2].
In Vivo	Tyloxapol (Triton WR1339, 50 mg/kg) causes significant (P < 0.05) decreases in the activities of the AChE and MAO enzymes in rat plasma and brain[1].Tyloxapol leads to significant (P < 0.05) reduction in the plasma urea, creatinine, and bilirubin[1]. Animal Model:
Name	Tyloxapol
CAS	25301-02-4
Formula	(C15H21O(C2H4O)m)n
Molar Mass	261.38 (monomer)
Appearance	Oil
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Heba Mohamed Abdou, et al. Triton WR-1339-induced hyperlipidemia, DNA fragmentation, neurotransmitters inhibition, oxidative damage, histopathological and morphometric changes: the protective role of soybean oil. The Journal of Basic and Applied Zoology volume 79, Article number: 51 (2018). [2]. Julijana Kristl, et al. Surface active stabilizer tyloxapol in colloidal dispersions exerts cytostatic effects and apoptotic dismissal of cells. Toxicol Appl Pharmacol. 2008 Oct 15;232(2):218-25.

Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s)