| Bioactivity | Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2]. | ||||||||||||
| Invitro | Silychristin exhibits a strong inhibition of MCT8-mediated T3 uptake with an IC50 of 110 nM in MCT8 overexpressing MDCK1-cells[2].Silychristin causes no cytotoxic for fibroblasts[3].Silychristin (6.5-75 μM; 24 hours) diminishes UVA toxicity and reduces ROS generation, and the protective effect is dose-dependent[3].Silychristin (12.5μM, 25μM) reduces the metalloproteinase-1 (MMP-1) level in cells[3]. Cell Viability Assay[3] Cell Line: | ||||||||||||
| Name | Silychristin | ||||||||||||
| CAS | 33889-69-9 | ||||||||||||
| Formula | C25H22O10 | ||||||||||||
| Molar Mass | 482.44 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Silychristin
CAS: 33889-69-9 F: C25H22O10 W: 482.44
Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silych
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