| Bioactivity | Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1]. |
| Invitro | Sauchinone (1, 3, 10, 30μm; 6 hours) inhibits LPS-inducible increase in the iNOS mRNA in Raw264.7 cells[1]. Sauchinone at the concentrations of 3 and 30 μm inhibits TNF-α production in LPS-treated cells by 40 and 50%, respectively[1]. |
| Name | Sauchinone |
| CAS | 177931-17-8 |
| Formula | C20H20O6 |
| Molar Mass | 356.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
Sauchinone
CAS: 177931-17-8 F: C20H20O6 W: 356.37
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible
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