| Bioactivity | Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 hydrochloride has a Ki of 4000 nM at the dopamine D2 receptor[1]. |
| Target | IC50: 16 nM (DTG site of sigma receptor), 19 nM (PPP site of sigma receptor)Ki: 4000 nM (Dopamine D2 receptor) |
| In Vivo | Administration of Sigma-LIGAND-1 hydrochloride reverseS amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 hydrochloride and its structural analogues have the potential antipsychotic activity[1]. |
| Name | Sigma-LIGAND-1 hydrochloride |
| CAS | 139652-86-1 |
| Formula | C27H34ClNO4 |
| Molar Mass | 472.02 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Erickson RH, et al. (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem. 1992 May 1;35(9):1526-35. |
Sigma-LIGAND-1 hydrochloride
CAS: 139652-86-1 F: C27H34ClNO4 W: 472.02
Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the
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