| Bioactivity | Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 has the potential for the neuropathic pain[1]. | ||||||||||||
| Target | IC50: 1.54μM (hERG). Ki : 1.14 nM (Sigma-1 receptor); 1239 nM (Sigma-2 receptor) | ||||||||||||
| Name | Sigma-1 receptor antagonist 3 | ||||||||||||
| CAS | 1639220-17-9 | ||||||||||||
| Formula | C19H23ClFN3O | ||||||||||||
| Molar Mass | 363.86 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23. |
Sigma-1 receptor antagonist 3
CAS: 1639220-17-9 F: C19H23ClFN3O W: 363.86
Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.1
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.