| Bioactivity | Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism[1]. | |||||||||
| Target | TRPA1 channel | |||||||||
| Invitro | Umbellulone, from µM to sub-mM concentrations, selectively stimulates transient receptor potential ankyrin 1-expressing HEK293 cells[1]. | |||||||||
| In Vivo | Umbellulone (50–250 nM/5ul) causes an acute nocioceptive response in a dose-dependent manner in Trpa1+/+ mice[1].Umbellulone (150 µg/kg; intravenous or intranasal) do not affect systemic blood pressure[1].Umbellulone (30-150 μg/kg; i.v.) increases meningeal blood flow in a dose-dependent manner[1]. Animal Model: | |||||||||
| Name | Umbellulone | |||||||||
| CAS | 546-78-1 | |||||||||
| Formula | C10H14O | |||||||||
| Molar Mass | 150.22 | |||||||||
| Appearance | Oil | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Nassini R, et al. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain. 2012 Feb;135(Pt 2):376-90. |