| Bioactivity | SiR-Hoechst is a far-red fluorescent DNA probe being used widely for time-lapse imaging of living cells. SiR-Hoechst is minimally toxic at concentrations as high as 10-25 µM. SiR-Hoechst induces DNA damage responses and G2 arrest at concentrations well below 1 µM[1][2]. |
| Invitro | SiR-Hoechst 具有一些明显的优势：它对 DNA 具有选择性； DNA 结合后其荧光增强； 它由远红光激发，避免了传统 Hoechst 染料所需的紫外线造成的损害； 它与活细胞超分辨率显微镜兼容[1]。 0 --> SiR-Hoechst 相关抗体: |
| Name | SiR-Hoechst |
| Formula | C56H59N9O4Si |
| Molar Mass | 950.21 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sen O, et al. The live cell DNA stain SiR-Hoechst induces DNA damage responses and impairs cell cycle progression. Sci Rep. 2018 May 21;8(1):7898. [2]. Lukinavičius G, et al. SiR-Hoechst is a far-red DNA stain for live-cell nanoscopy. Nat Commun. 2015 Oct 1;6:8497. |