| Bioactivity | Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9); SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM)[1]. | ||||||||||||
| Target | IC50: Serpin B9 | ||||||||||||
| In Vivo | Serpin B9-IN-1 (BTCA) 在多种肿瘤转移模型中抑制骨转移 (BM)。Serpin B9-IN-1 (50 mg/kg/d; ip; 14 d) 在尾动脉注射 (CA) 有 LLC1-BM3 的小鼠骨转移模型中有效降低了转移癌细胞的存活率和转移比例[1]。Serpin B9-IN-1 (300 μg/d; ip; 14 d) 有效延迟了 LLC1-BM3 细胞组发生骨转移（BM）的平均时间[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | ||||||||||||
| CAS | 154235-77-5 | ||||||||||||
| Formula | C8H5NO3 | ||||||||||||
| Molar Mass | 163.13 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Huang Y, et al. Mass Spectrometry-Based Proteomics Identifies Serpin B9 as a Key Protein in Promoting Bone Metastases in Lung Cancer. Mol Cancer Res. 2024 Apr 2;22(4):402-414. |
Serpin B9-IN-1
CAS: 154235-77-5 F: C8H5NO3 W: 163.13
Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9); SB9 is a natural inhibitor of granzyme
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