| Bioactivity | Saredutant is a selective NK2 receptor antagonist. | ||||||||||||
| In Vivo | Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant has dose-dependent effects on swim test immobility, with the low dose of 1 mg/kg having no effect and the doses of 3 and 10 mg/kg significantly reducing immobility[1]. | ||||||||||||
| Name | Saredutant | ||||||||||||
| CAS | 142001-63-6 | ||||||||||||
| Formula | C31H35Cl2N3O2 | ||||||||||||
| Molar Mass | 552.53 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Overstreet DH, et al. Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with Desipramine in an animal model of depression. Pharmacol Biochem Behav. 2010 Aug;96(2):206-10. |