| Bioactivity | Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM[1]. |
| Invitro | Sarafotoxin S6a is a rather weak agonist effect in guinea-pig aorta, the eliting concentration (EC50) is 150 nM in guinea-pig aorta[1]. |
| Name | Sarafotoxin S6a |
| CAS | 126738-34-9 |
| Sequence | Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridge:Cys1-Cys15;Cys3-Cys11) |
| Shortening | CSCKDMTDKECLNFCHQDVIW (Disulfide bridge:Cys1-Cys15;Cys3-Cys11) |
| Formula | C105H156N28O34S5 |
| Molar Mass | 2514.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. P Schoeffter, et al. Differences between endothelin receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur J Pharmacol |
Sarafotoxin S6a
CAS: 126738-34-9 F: C105H156N28O34S5 W: 2514.85
Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile simila
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