AChE-IN-12_product_DataBase

Bioactivity	AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC50s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8 µM). AChE-IN-12 has remarkable inhibition of self- and Cu2+-induced Aβ1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease[1].
Target	IC50: 0.41 μM (rat AChE), 1.88 μM (electric eel AChE), 8.8 µM (huMAO-B)
Invitro	AChE-IN-12 (compound 17f）(10-100 μM) exhibits no obvious cytotoxicity until the concentration increased up to 50 µM[1].AChE-IN-12 (10 and 50 μM) adds up the cell viability of H2O2-induced PC12 cells[1]. Cell Cytotoxicity Assay Cell Line:
Name	AChE-IN-12
CAS	2764664-52-8
Formula	C33H41NO7
Molar Mass	563.68
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sang Z, Song Q, Cao Z, Deng Y, Zhang L. Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2022;37(1):69-85.

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