| Bioactivity | Salvinorin A is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.3 nm. Salvinorin A is a non-nitrogenous neoclerodane isolated from Salvia divinorum. | |||||||||
| Target | Ki:4.3 nm (kappa-opioid receptor) | |||||||||
| Invitro | Salvinorin A (Divinorin A)(0.01-10 pM; pre-30 minues; 24 hours) does not affect the membrane function after 24-h exposure in macrophages[1].Salvinorin A (Divinorin A) (0.01-10 pM; pre-30 minues; 18 hours) before LPS stimulation causes a significant and concentrationdependent manner reduction of LPS-stimulated nitrite levels, the IC50 (95% CL) of salvinorin A inhibitory effect was 6.5×10−13M[1].Salvinorin A (Divinorin A) (0.01-10 pM; pre-30 minues; 18 hours) incubates 30 min before LPS stimulation, reduces in concentration-dependent manner the LPSinduced iNOS, but not COX-2, hyperexpression, reaching a statistical significance at the 10 pM concentration[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Salvinorin A 相关抗体: | |||||||||
| In Vivo | Salvinorin A (intraperitoneal injection; 0.5-2 mg/kg; pre-treatment 30 minutes) at the 0.5 mg/kg dose is the most effective one, at the dose of 0.5 mg/kg, significantly inhibits oedema during the first 6 h; at the dose of 1 mg/kg, salvinorin A significantly reduces the oedema only 4 h after carrageenan injection; at the highest doses tested (2 mg/kg), salvinorin A fails to evoke significant changes on the carrageenan-induced paw oedema[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| CAS | 83729-01-5 | |||||||||
| Formula | C23H28O8 | |||||||||
| Molar Mass | 432.46 | |||||||||
| Appearance | 固体 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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| Reference | [1]. Butelman ER, et al. Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Front Pharmacol. 2015 Sep 8;6:190. [2]. John TF, et al. The antinociceptive effect of salvinorin A in mice.Eur J Pharmacol. 2006 Sep 18;545(2-3):129-33. Epub 2006 Jul 4. |
Salvinorin A
CAS: 83729-01-5 F: C23H28O8 W: 432.46
Salvinorin A is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.
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