| Bioactivity | NS-062 is an orally active, irreversible targeted covalent inhibitor for EGFR, and exhibits antiproliferative efficacy in drug-resistant double mutated H1975 cell with an IC50 of 0.19 μM. NS-062 exhibits antitumor efficacy in mouse H1975 xenograft model[1]. |
| CAS | 2226257-92-5 |
| Formula | C28H30Cl2F2N6O4 |
| Molar Mass | 623.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shindo N, et al., Selective and reversible modification of kinase cysteines with chlorofluoroacetamides. Nat Chem Biol. 2019 Mar;15(3):250-258. |
NS-062
CAS: 2226257-92-5 F: C28H30Cl2F2N6O4 W: 623.48
NS-062 is an orally active, irreversible targeted covalent inhibitor for EGFR, and exhibits antiproliferative efficacy i
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