Salmeterol-d5

CAS: 1093433-84-1 F: C25H32D5NO4 W: 420.60

Salmeterol-d5 is a deuterated labeled Salmeterol. Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor

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Bioactivity	Salmeterol-d5 is a deuterated labeled Salmeterol[1]. Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[2].
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。Salmeterol (0.001-25 μM) 抑制人 T 淋巴细胞增殖[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Salmeterol-d5 相关抗体:
In Vivo	Salmeterol (0.16 mg/kg)、Formoterol (0.32 mg/kg) 联合处理对慢性阻塞性肺疾病 (COPD) 小鼠具有改善作用[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1093433-84-1
Formula	C25H32D5NO4
Molar Mass	420.60
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Malcolm Johnson. Effects of beta2-agonists on resident and infiltrating inflammatory cells. J Allergy Clin Immunol. 2002 Dec;110(6 Suppl):S282-90. [3]. Panayiotis A Procopiou, et al. The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group. Bioorg Med Chem. 2011 Oct 15;19(20):6026-32. [4]. Zhiyuan Wang, et al. Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease. Exp Ther Med. 2018 Feb;15(2):1538-1545.