| Bioactivity | STING modulator-3 is a STING inhibitor. STING modulator-3 inhibits R232 STING with an Ki value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells[1]. |
| Invitro | STING modulator-3 (AIP01) (10 μM；3 h，24 h) 分别不影响处理 THP-1 细胞 3 h 时，IRF-3 的磷酸化或是处理 24 h 时，对 TNF-β 的诱导[1]。 |
| Name | STING modulator-3 |
| CAS | 2839639-94-8 |
| Formula | C18H17N9O |
| Molar Mass | 375.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gajiwala KS, et al. Imidazole derivatives as STING modulators and their preparation, pharmaceutical compositions and use in the treatment of cancer: World Intellectual Property Organization, WO2022195462. 2022-09-22. |
STING modulator-3
CAS: 2839639-94-8 F: C18H17N9O W: 375.39
STING modulator-3 is a STING inhibitor. STING modulator-3 inhibits R232 STING with an Ki value of 43.1 nM in scintillati
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