Antitumor agent-87_product_DataBase

Bioactivity	Antitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a Ki value of 0.23 µM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity[1].
Invitro	Antitumor agent-87 (compound 10) 在人肝微粒体、小鼠肝微粒体和大鼠肝微粒体中的半衰期 (t1/2) 分别为 70、44、107 分钟[1]。Antitumor agent-87 (1250 nM) 诱导细胞周期停滞在 G2/M 期[1]。Antitumor agent-87 (0-12500 nM; 72 h) 具有抗增殖活性，对 HT-1080CYP1A1, HT-1080empty, HT-1080, MDA-MB-231, MDA-MB-468, T47D, SK-BR-3, MCF7细胞的 IC50 值分别为 500, 8800, 6800, >12500, 210, 1100, 79, 43 nM[1]。 Cell Proliferation Assay[1] Cell Line:
In Vivo	Antitumor agent-87 (0.1 µg/egg) 在鸡胚中表现出抗肿瘤活性[1]。 Animal Model:
Name	Antitumor agent-87
CAS	1422527-88-5
Formula	C22H28N2O6S
Molar Mass	448.53
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chavez Alvarez AC, et al. Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes. J Med Chem. 2023 Feb 23;66(4):2477-2497.

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