STING agonist-31_product_DataBase

Bioactivity	STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1].
Invitro	STING agonist-31 (化合物 40) 激活 h-STING 和 m-STING，EC50 值为 0.24 和 39.51 μM[1]。STING agonist-31 (0-10 μM，24 h) 激活 ISG 信号和 NF-κB 信号[1]。
In Vivo	STING agonist-31 (化合物 40) (10 mg/kg，静脉注射) 抑制 4T1 和 CT26 小鼠肿瘤模型中的肿瘤生长[1]。STING agonist-31 (1 mg/kg，静脉注射) 在大鼠中显示出 T1/2：0.697 h，AUClast 678 h•ng/mL[1]. Animal Model:
Name	STING agonist-31
CAS	2719001-44-0
Formula	C43H51N15O6
Molar Mass	873.96
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Song Z, et al. Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists. J Med Chem. 2021 Feb 11;64(3):1649-1669.

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