| Bioactivity | STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells[1]. |
| Invitro | STAT3/AKT-IN-1 抑制胃癌细胞 SGC-7901 和 BGC-823 的细胞活力，IC50 分别为 1.39 μM 和 2.92 μM[1]。STAT3/AKT-IN-1 (2.5-10 μM) 剂量依赖地在 G2/M 期阻滞细胞周期，抑制 SGC-7901 细胞增殖和迁移，诱导细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> STAT3/AKT-IN-1 相关抗体: Cell Migration Assay [1] Cell Line: |
| In Vivo | STAT3/AKT-IN-1 (15 mg/kg静脉注射，每天一次共 20 天) 在 SGC-7901 异种移植 BALB/c 小鼠中表现出抗癌活性，且没有明显毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C23H22O4 |
| Molar Mass | 362.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gan X, et al., Design, synthesis, and evaluation of cyclic C7-bridged monocarbonyl curcumin analogs containing an o-methoxy phenyl group as potential agents against gastric cancer. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2314233. |