| Bioactivity | MD6a is a melatonin derivative with inhibitroy activity towards PARP-1, which maintains proteins hemostasis and improves mitochondrial function through TOR/HSF-1 signaling. MD6a a neuroprotective effect[1]. |
| Invitro | MD6a (10 μM) 抑制 PARP-1，通过靶向 hsp-4 和 hsp-6 下调 let-363/hsf-1 信号传导，从而减少 α-syn 聚集并增强 C. elegans 中的线粒体功能[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MD6a 相关抗体: Real Time qPCR[1] Cell Line: |
| Formula | C21H22N2O2 |
| Molar Mass | 334.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ma QW, et al., Melatonin derivative 6a as a PARP-1 inhibitor for the treatment of Parkinson's disease. Front Pharmacol. 2024 Feb 27;15:1363212. |