STAT3-IN-5_product_DataBase

Bioactivity	STAT3-IN-5 is a potent STAT3 inhibitor. STAT3-IN-5 inhibits STAT3-Y705 phosphorylation with an EC50 value of 170 nM. STAT3-IN-5 inhibits cytokine induced JAK activation. STAT3-IN-5 induces apoptosis. STAT3-IN-5 can be used in research of cancer[1].
Invitro	STAT3-IN-5 (compound 8; 0-2 μM; 1 h) 抑制 U266 细胞中的 STAT3 磷酸化[1]。STAT3-IN-5 (0-2 μM; 1 h) 抑制 U266 细胞中细胞因子诱导的 JAK1、JAK2 和 Tyk2 磷酸化[1]。 Western Blot Analysis[1] Cell Line:
Name	STAT3-IN-5
CAS	1041438-68-9
Formula	C19H7F7N2O3
Molar Mass	444.26
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Xu J, et, al. Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem. 2008 Jul 24;51(14):4115-21.

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