| Bioactivity | SMBA1 is a potent Bax agonist with a Ki value of 43.3 nM. SMBA1 enhances the Bax expression. SMBA1 shows anti-tumor activity. SMBA1 has the potential for the research of lung cancer[1]. |
| Invitro | SMBA1 通过阻断 S184 磷酸化、促进 Bax 插入线粒体膜并形成 Bax 寡聚体来诱导 Bax 的构象变化显示 Bax 激动剂活性[1]。SMBA1 (0, 0.1, 1, 5, 10 µM; 24 h) 在 A549 细胞中以剂量依赖性方式增强 Bax 表达[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | SMBA1 (2、10、40、60 mg/kg；腹腔注射；每天一次，持续 10 天) 在小鼠体内显示出抗肿瘤活性[1]。 Animal Model: |
| Name | SMBA1 |
| CAS | 906440-37-7 |
| Formula | C20H13NO3 |
| Molar Mass | 315.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xin M, et al. Small-molecule Bax agonists for cancer therapy. Nat Commun. 2014 Sep 17;5:4935. |