| Bioactivity | STAT3-IN-38 (Compound 4m) is an inhibitor of STAT3 (KD of rhSTAT3: 45.33 µM). STAT3-IN-38 binds to the SH2 domain of STAT3 protein and suppresses the STAT3’s phosphorylation at site pTyr705 as well as its downstream genes (Survivin and Mcl-1). STAT3-IN-38 could block cell-cycle and induce Apoptosis in colorectal cancer cells[1]. |
| Invitro | STAT3-IN-38 (0.5-1 μM, 6 h) 可抑制 HCT116 细胞中 STAT3 的磷酸化，并降低 STAT3 靶蛋白 survivin 和骨髓细胞白血病 1 (Mcl-1) 的水平[1]。STAT3-IN-38 (0.02-12.5 μM, 48 h) 可抑制 A549、HCT116 和 HepG2 细胞的增殖[1]。STAT3-IN-38 (1-5 μM, 48 h) 可诱导 HCT116 细胞凋亡和细胞周期停滞[1]。STAT3-IN-38 (1-10 µM，6 天) 可降低人结直肠癌类器官组织 (CCOs) 的活力[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> STAT3-IN-38 相关抗体: Cell Cycle Analysis[1] Cell Line: |
| CAS | 3033049-16-7 |
| Formula | C35H45NO3S |
| Molar Mass | 559.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xu, et al. Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition. Journal of enzyme inhibition and medicinal chemistry. 2022, 37(1), 236–251. |