SR33805 oxalate_product_DataBase

Bioactivity	SR33805 oxalate is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 oxalate blocks L-type but not T-type Ca2+ channels. SR33805 oxalate can be used for the research of acute or chronic failing hearts[1][2].
Invitro	SR33805 (0.01-10 µM；3天) oxalate 以剂量依赖的方式抑制生长因子诱导的SMC增殖 (0.20 0 --> SR33805 oxalate 相关抗体: Cell Viability Assay[3] Cell Line:
In Vivo	SR33805 (20 mg/kg；单次腹腔注射) 改善大鼠心肌梗死 (MI) 心脏的收缩末期应变和短轴缩短分数[2]。SR33805 (5 mg/kg/天；口服38天) 显著减少猪的内膜增生[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	121346-33-6
Formula	C34H42N2O9S
Molar Mass	654.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Romey G, et, al. Effects of two chemically related new Ca2+ channel antagonists, SR33557 (fantofarone) and SR33805, on the L-type cardiac channel. Eur J Pharmacol. 1994 Sep 22; 263(1-2): 101-5. [2]. Mou YA, et, al. Beneficial effects of SR33805 in failing myocardium. Cardiovasc Res. 2011 Aug 1; 91(3): 412-9. [3]. Hainaud P, et, al. The calcium inhibitor SR33805 reduces intimal formation following injury of the porcine carotid artery. Atherosclerosis. 2001 Feb 1; 154(2): 301-8.

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