| Bioactivity | SPR39 is a potent SARS-CoV-2 main protease inhibitor with Ki values of 0.252, 3.38, 7.88 µM for SARS-CoV-2 Mpro, hCatL, hCatB, respectively. SPR39 shows antiviral and cytotoxicity[1]. |
| Target | Ki: 0.252 µM (SARS-CoV-2 Mpro); 3.38 µM (hCatL); 7.88 µM (hCatB) |
| Invitro | SPR39 (0-100 µM; 1 h) 表现出抗病毒和细胞毒性，对 SARS-CoV-2 感染的 Huh-7-ACE2 细胞的 EC50 为 1.5 µM，对未感染的 Huh-7-ACE2 细胞的 CC50 值为 100 µM[1]。 |
| Name | SPR39 |
| Formula | C24H31N3O5 |
| Molar Mass | 441.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Previti S, et al. Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors. Eur J Med Chem. 2022 Dec 15;247:115021. |