| Bioactivity | SIRT5 inhibitor 5 is a potent SIRT5 inhibitor with an IC50 value of 0.21 µM. SIRT5 inhibitor 5 does not occupy the NNAD+ -binding pocket and acts as a substrate-competitive inhibitor[1]. |
| Invitro | SIRT5 inhibitor 5 (compound 47) (0-10 µM) 在不同浓度的 NAD+ (50, 100, 200, 400, 800 µM) 中显示抑制活性没有显着变化，在 Ac-K(Suc)-AMC（10、30、90、270 µM）浓度增加的情况下降低了抑制活性[1]。 |
| Name | SIRT5 inhibitor 5 |
| Formula | C21H14ClN3O3S |
| Molar Mass | 423.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yao J, et al. Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors. Eur J Med Chem. 2022 Dec 16;247:115024. |