| Bioactivity | SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation[1]. |
| In Vivo | SPL-334 (0.1-1 mg/kg; 鼻内给药; 每日一次, 持续 7 天; 带有 DO11.10 CD4+ Th2 异种移植物的 BALB/c 受体小鼠) 导致过敏性气道炎症减少[1] . Animal Model: |
| Name | SPL-334 |
| CAS | 688347-51-5 |
| Formula | C22H15N3O3S2 |
| Molar Mass | 433.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ferrini ME, et, al. S-nitrosoglutathione reductase inhibition regulates allergen-induced lung inflammation and airway hyperreactivity. PLoS One. 2013 Jul 25;8(7):e70351. |
SPL-334
CAS: 688347-51-5 F: C22H15N3O3S2 W: 433.50
SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR)inhibitor. SPL-334 causes a significant reductio
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