| Bioactivity | SPA70 is a potent and selective antagonist of human pregnane X receptor (hPXR), with an IC50 of 540 nM (Ki=390 nM). SPA70 can enhance the chemosensitivity of cancer cells[1]. | |||||||||
| Target | IC50: 540 nM (hPXR) | |||||||||
| Name | SPA70 | |||||||||
| CAS | 931314-31-7 | |||||||||
| Formula | C21H25N3O4S | |||||||||
| Molar Mass | 415.51 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Lin W, et, al. SPA70 is a potent antagonist of human pregnane X receptor. Nat Commun. 2017 Sep 29;8(1):741. |