SMO-IN-4_product_DataBase

Bioactivity	SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC50: 24 nM). SMO-IN-4 has antitumor activity[1].
Invitro	SMO-IN-4 (10 µM) 对所有 CYP 亚型的抑制作用极小，对 hERG 的抑制也较低 (IC50 = 38 µM)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SMO-IN-4 相关抗体:
In Vivo	在 Ptch1+/- 小鼠髓母细胞瘤皮下异种移植模型中，SMO-IN-4 (50 mg/kg，每日口服灌胃) 可导致皮下肿瘤消退[2]。 SMO-IN-4 (Compound 24)的药代特性[2]。 Species
CAS	1567963-99-8
Formula	C24H27ClN6O
Molar Mass	450.96
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lu W, et al. Design, Synthesis, and Structure-Activity Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity. ACS Chem Neurosci. 2017 Sep 20;8(9):1980-1994.

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