| Bioactivity | MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death[1]. |
| Invitro | MPI-0441138 (5 nM；72 h) 诱导 22Rv1、MDA-MB-231、Caco-2 和 Du145 细胞中的细胞凋亡和 DNA 片段化[1]。MPI-0441138 (5 nM; 1 h) 诱导 AIF 和 细胞色素 c 从线粒体易位至细胞质和细胞核[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MPI-0441138 相关抗体: Apoptosis Analysis[1] Cell Line: |
| CAS | 827030-33-1 |
| Formula | C16H14ClN3O |
| Molar Mass | 299.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67(12):5865-71. |
MPI-0441138
CAS: 827030-33-1 F: C16H14ClN3O W: 299.75
MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochr
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