| Bioactivity | SLB1122168 formic is a potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM[1]. | ||||||||||||
| In Vivo | SLB1122168 (33p；10 mg/kg；腹腔注射；一次) 导致循环淋巴细胞剂量依赖性减少[1]。在大鼠中，剂量为 10 mg/kg 时，SLB1122168 (33p) 在给药后 2 小时达到最大浓度 4 μM，24 小时内浓度≥1 μM，半衰期为 8 小时[1]。 | ||||||||||||
| Name | SLB1122168 formic | ||||||||||||
| Formula | C23H37N3O3 | ||||||||||||
| Molar Mass | 403.56 | ||||||||||||
| Appearance | Solid-liquid mixture | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Ariel L Burgio, et al. 2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). J Med Chem. 2023 Apr 27;66(8):5873-5891. |