| Bioactivity | SIRT6 activator 12q is potent, selective and orally active SIRT6 activator with IC50 values of 171.20, >200, >200, >200, 0.58 μM for SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, respectively. SIRT6 activator 12q inhibits cell growth and migration. SIRT6 activator 12q induces Apoptosis and cell cycle arrest at G2 phase. SIRT6 activator 12q shows anticancer activity[1]. | ||||||||||||
| Invitro | SIRT6 activator 12q (2.5, 5, 10 µM; 14, 18 days) 以剂量依赖性方式抑制 PANC-1、BXPC-3、MIAPaCa-2 和 AsPC-1 细胞的集落形成[1] .SIRT6 activator 12q (10, 25, 50 µM; 48 h) 以剂量依赖性方式诱导细胞凋亡和细胞周期停滞在 G2 期[1]。SIRT6 activator 12q (12.5, 25, 50 µM; 48 h) 以剂量依赖性方式降低 PANC-1 和 BXPC-3 细胞中 H3K9ac、H3K18ac 和 H3K56ac 的蛋白表达[1]。 Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | SIRT6 activator 12q | ||||||||||||
| CAS | 2601734-99-8 | ||||||||||||
| Formula | C31H22N2O2 | ||||||||||||
| Molar Mass | 454.52 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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SIRT6 activator 12q
CAS: 2601734-99-8 F: C31H22N2O2 W: 454.52
SIRT6 activator 12q is potent, selective and orally active SIRT6 activator with IC50 values of 171.20, >200, >200, >200,
Data collection：peptidedb@qq.com
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