| Bioactivity | SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC50 of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease[1]. |
| Target | SIRT2 |
| Invitro | SIRT2-IN-10 (Compound 12) (0-50 μM; 72 h) inhibits the proliferation of MCF-7 cells in a concentration-dependent manner[1].SIRT2-IN-10 (6.25-50 μM; 6 h) increased the acetylation level of α-tubulin in a concentration-dependent manner in MCF-7 cells[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | SIRT2-IN-10 |
| CAS | 296793-09-4 |
| Formula | C28H21N5OS |
| Molar Mass | 475.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shengyong Yang, et al. The purposes of 5H- [1,2,4] triazine [5,6-b] indole derivatives of 3 substitutions. Patent CN108309982A. |
SIRT2-IN-10
CAS: 296793-09-4 F: C28H21N5OS W: 475.56
SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC50 of 1.3 μM. SIRT2-IN-10 can be used for the research
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