TAN-67 dihydrobromide_product_DataBase

Bioactivity	TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a Ki value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke[1][2].
Invitro	TAN-67 (SB-205607) dihydrobromide 高效 (EC50 = 1.72 nM) 抑制毛喉素刺激的 cAMP 在由完整的中国仓鼠卵巢细胞表达的人 delta-阿片受体上的积累，但在人 mu-阿片受体上的效力较低 (EC50 = 1520 nM)由完整的 B82 小鼠成纤维细胞表达[1]。
In Vivo	TAN-67 (SB-205607; 1.5-4.5 mg/kg; i.v.; once) dihydrobromide 减少 I/R 引起的脑损伤的梗塞体积[2]。TAN-67 (3 mg/kg; i.v.; once) dihydrobromide 改善 I/R 后的生存和神经行为表现[2]。TAN-67 (3 mg/kg; i.v.; once; 成年 C57BL/6J 雄性小鼠) dihydrobromide 在早期时间点 (6 h) 增加总 APP 和成熟 APP (APPm) 水平和 APP 处理[2]。 Animal Model:
Name	TAN-67 dihydrobromide
CAS	1217628-73-3
Formula	C23H26Br2N2O
Molar Mass	506.27
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Knapp RJ, et, al. Properties of TAN-67, a nonpeptidic delta-opioid receptor agonist, at cloned human delta- and mu-opioid receptors. Eur J Pharmacol. 1995 Oct 15;291(2):129-34. [2]. Min JW, et, al. The non-peptidic δ-opioid receptor agonist Tan-67 mediates neuroprotection post-ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice. J Neurochem. 2018 Feb;144(3):336-347.

PeptideDB

TAN-67 dihydrobromide

CAS: 1217628-73-3 F: C23H26Br2N2O W: 506.27