| Bioactivity | SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe3+ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM)[1]. |
| Target | SHP1 |
| Name | SHP1-IN-1 |
| CAS | 2956720-62-8 |
| Formula | C22H23N5O4 |
| Molar Mass | 421.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yan X, et al. Novel imidazo[1,2,4] triazole derivatives: Synthesis, fluorescence, bioactivity for SHP1. Eur J Med Chem. 2024 Feb 5;265:116027. |
SHP1-IN-1
CAS: 2956720-62-8 F: C22H23N5O4 W: 421.45
SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 d
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